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KMID : 0356620160310020320
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Journal of Korean Society of Endocrinology
2016 Volume.31 No. 2 p.320 ~ p.327
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C-Peptide-Based Index Is More Related to Incident Type 2 Diabetes in Non-Diabetic Subjects than Insulin-Based Index
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Kim Jong-Dai
Kang Sung-Ju
Lee Min-Kyung
Park Se-Eun
Rhee Eun-Jung
Park Cheol-Young
Oh Ki-Won
Park Sung-Woo
Lee Won-Young
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Abstract
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Background: Diabetes can be efficiently prevented by life style modification and medical therapy. So, identification for high risk subjects for incident type 2 diabetes is important. The aim of this study is to identify the best β-cell function index to identify high risk subjects in non-diabetic Koreans.
Methods: This is a retrospective longitudinal study. Total 140 non-diabetic subjects who underwent standard 2-hour 75 g oral glucose tolerance test from January 2007 to February 2007 at Kangbuk Samsung Hospital and followed up for more than 1 year were analyzed (mean follow-up, 54.9±16.4 months). The subjects were consist of subjects with normal glucose tolerance (n=44) and subjects with prediabetes (n=97) who were 20 years of age or older. Samples for insulin and C-peptide levels were obtained at 0 and 30 minutes at baseline.
Results: Thirty subjects out of 140 subjects (21.4%) developed type 2 diabetes. When insulin-based index and C-peptide-based index are compared between progressor and non-progressor to diabetes, all C-peptide-based indices were statistically different between two groups, but only insulinogenic index and disposition index among insulin-based index were statistically different. C-peptide-based index had higher value of area under receiver operating characteristic curve (AROC) value than that of insulin-based index. "C-peptidogenic" index had highest AROC value among indices (AROC, 0.850; 95% confidence interval, 0.761 to 0.915). C-peptidogenic index had significantly higher AROC than insulinogenic index (0.850 vs. 0.731 respectively; P=0.014).
Conclusion: C-peptide-based index was more closely related to incident type 2 diabetes in non-diabetic subjects than insulin-based index.
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KEYWORD
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Glucose tolerance test, C-peptide, Insulin secretion and incident diabetes
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